RNCP brainstorm Protocol for October 2021:
Aim:
Improve clotting factors
Prevent excessive blood loss
Ensure circulation within the vasculature
Current research findings:
Evidence for the use of Saffron in DIC
The present study was designed to evaluate the effect of crocetin on thrombosis procedure using a rabbit model of bacterial endotoxin-induced DIC. Crocetin administration (3 mg/kg), 30 min before the beginning of endotoxin infusion, improved DIC-related haemostatic indices such as platelet blood counts (P≤ 0.05), blood plasma fibrinogen and protein C concentration (P≤ 0.05). In addition, it ameliorated DIC-associated disease and fibrin deposition in the glomeruli (P≤ 0.05). These results indicate that crocetin reveals a preventive antithrombotic role in vivo and prescribe further investigation on the possibility of developing crocetin-based DIC treatment modalities
Pub med article ARTICLE: 23358225
DOI: 10.1097/MBC.0b013e32835bdc8f
Capsella bursa pastoris monograph by Europen drug encyclopaedia